Shalin Mehta
Shalin Mehta
Platform Leader, Advanced Optical Microscopy,
499 Illinois Street, 4th floor, 
San Francisco, CA 94404.

email: shalin <dot> mehta <at> czbiohub <dot> org
twitter: @mattersoflight
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Biography

Dr. Shalin Mehta received his Ph.D. at the National University of Singapore, where he worked on optics and biological microscopy. His thesis research led to better mathematical models and novel approaches for imaging cellular morphology. As a postdoctoral fellow and staff scientist at the Marine Biological Laboratory in Woods Hole, Mehta developed novel imaging and computational methods for detecting molecular order across a range of scales in living systems. He built an instantaneous fluorescence polarization microscope that revealed the dynamics of molecular assemblies by tracking the orientation and position of single molecules in live cells. As Leader of Advanced Optical Microscopy at CZ Biohub, Mehta is developing integrated imaging and computational platforms and participating in the Cell Atlas Initiative, Infectious Disease Initiative, and other collaborative initiatives.

His recent work has been covered by MBL news, University of Chicago news, GizmodoBioTechniquesOptics & Photonics News, and Human Frontier Science Program.

Research

Our interdisciplinary research spans fields of optics, signal processing, and biophysics.  We focus on imaging physical properties of biological systems with increasing precision, resolution, and throughput. 

We pursue technological advances in following areas:
  • Live cell super-resolution microscopy.
  • Label-free microscopy using phase and polarization of light.
  • Exploiting multiple light-matter interactions to obtain rich description of cells, organoids, and tissues.
We pursue collaborative biological research in following areas:
  • Mapping molecular dynamics and sub-cellular architecture in cells, organoids, and tissues to enable building of image based cell atlas.
  • Measuring biogenesis of viruses in mammalian cells to discover new therapeutic opportunities.
  • Analyzing biogeography of commensal microbes and pathogenic biofilms.