Shalin Mehta
Shalin Mehta
Platform Leader, Advanced Optical Microscopy,
499 Illinois Street, 4th floor, 
San Francisco, CA 94404.

email: shalin <dot> mehta <at> czbiohub <dot> org
twitter: @mattersoflight
Google Scholar 


Mehta received his Ph.D. at the National University of Singapore, where he worked on optics and biological microscopy. His thesis research led to better mathematical models and novel approaches for imaging cellular morphology. As a postdoctoral fellow and staff scientist at the Marine Biological Laboratory in Woods Hole, Mehta developed novel imaging and computational methods for detecting molecular order across a range of scales in living systems. He built an instantaneous fluorescence polarization microscope that revealed the dynamics of molecular assemblies by tracking the orientation and position of single molecules in live cells. At CZ Biohub, Mehta and his team seek to measure physical properties of biological systems with increasing precision, resolution, and throughput. 

His recent work has been covered by 
MBL news, University of Chicago news, GizmodoBioTechniquesOptics & Photonics News, and Human Frontier Science Program.


We exploit diverse light-matter interactions and algorithms to measure architecture and dynamics of molecules, organelles, cells, organoids, and tissues. These advanced microscopy platforms enable data driven discovery of biological mechanisms and therapeutic opportunities in collaboration with CZ Biohub’s initiatives, platforms, and partners. Our interdisciplinary research spans fields of optics, image analysis, and biophysics.  

We pursue technological advances in following areas:

  • Measurement of nanoscale order of molecules in 3D.
  • Label-free microscopy using phase and polarization of light.
  • Exploiting multiple light-matter interactions to obtain rich description of cells, organoids, and tissues.
Our current collaborative biological research is in following areas:
  • Analyzing lifecycle and biogenesis of viruses in mammalian cells to discover new therapeutic opportunities.
  • Mapping and modeling the dynamics of multiple organelles and molecules in live cells.

Latest News

  • Elliot Mount joins the lab! Welcome Elliot.
    Posted Jan 7, 2018, 11:24 PM by Shalin Mehta
  • We are recuriting! Develop microscopes, assays, and algorithms to measure physical properties of biological systems with us! We are looking for an optical physicist, a computational microscopist, and a biophysicist.
    Posted Jan 7, 2018, 11:29 PM by Shalin Mehta
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